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Bioactive formulations and sustainable chemistry : towards new drugs
The design of a drug involves a critical stage : its preparation or "formulation" that associates the active principle [1] with an excipient [2] to make it stable and deliver it where it is expected to act. Chemists thus seek to discover the best form of preparation and administration of the active principle.
Researchers from Toulouse have developed an innovative concept : the implementation of bioactive formulations. This new way of preparing drugs is based on the specific synthesis of an active "amphiphilic" principle, i.e. which likes to surround itself with water and lipids. Under these conditions, it becomes the actor of its own formulation, while providing the desired bioactivity. This bioactive, amphiphilic molecule indeed has the valuable characteristic to "self-organize" by forming assemblies, the nature of which is closely linked to the therapeutic activity.
This strategy is particularly well suited to the administration of dermal anti-inflammatory drugs, one of the major challenges of dermatological research. A new bioactive formulation, patented and industrially developed in partnership with Pierre Fabre Laboratories, very effective in treating atopic skin diseases [3] (including eczema) has been marketed through pharmacies.
Moreover, being developed using sugars from renewable resources means bioactive formulations are in line with an environmentally friendly "chemistry that serves sustainable development".
Laboratoire « Interactions moléculaires et réactivité chimique et photochimique », CNRS-Université Toulouse 3
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