n°28I quarterlyI January 2013 Live from the Labs | 13 w Biology When Scarring Cells Overdo It q scarring tissue of include medical devices such as artificial skeletal muscle after muscles, but also information storage and an injury.the processing tools in molecule-based com- with blue nucleus)12+ cells (greenadam puters. They also cover microrobots and produce excess new substances with novel properties, collagen (red). such as “sponge-like materials that can contract,” adds Giuseppone. The team’s next objective is to “bundle several fibers together to further amplify their move- ment” and “integrate other movements such as rotations.” 01.InstitutCharlesSadron(CNRS/universitéde Strasbourg). 02. duetal.,“Muscle-likeSupramolecularPolymers –IntegratedMotionfromThousandsofMolecular Machines,”Angew. Chem. Int. Ed.,2012.doi: 10.1002/ WITHPERMISSION anie.201208497. R u 03.Matièreetsystèmescomplexes(CNRS/université ASTEParis-VII).P T u NSTIT d CE /I TO du q this study made Edu EPRO the cover page of R A. Angewandte Chemie © A KG . International O edition. BYclémentInewallace wasrapidlyinducedinasubsetofperi- & H MB vascularcells,albeittransiently.These G ERLAG w rs researchers have identified cellsalsoexpressedhighlevelsofpro-in- CN cells involved in scarringthatmayplay flammatory cytokines and growth y-VCH asignificantroleinfibrosis,apathologi- factors. ILE © calhealingprocesswhichcanbelethal BylabelingAdAM12+cellsgenetically, whenitaffectsinternalorgans.1 thescientiststrackedthecellsasthey Whenanorganisinjured,thehealing moved and multiplied over the entire contactInformatIon: Ics,strasbourg. processinvolvesseveralfactors.Among processoftissuerepair.Thecellsspecifi- Nicolas Giuseppone these, collagen-producing myofibro- callygaverisetocollagen-overproducing > giuseppone@unistra.fr blastsmakeupthescar,whichisusually myofibroblasts during the scarring eliminatedoncethetissueregenerates. process.Furthermore,specificelimina- yetincertainchronicdiseases,the tionofAdAM12+cellswassufficientto scarringprocesspersists,leadingtofibro- decreasecollagenaccumulation. sis, with collagen-producing myofibro- “Inacuteinjury,thedevelopmentof un blastsaccumulatingtothepointofim- AdAM12+ cells is only transient. But in pairingorganfunction. certainchronicfibroticdiseases,theyare lpha centauri B q european Theoriginandregulationofmyofi- generated continuously, which might ISINGER astronomers have broblastsarestillunclear.“Weknewthat playaroleinexcesscollagendeposition,” /N.R discovered a planet a transmembrane protein called saysPeduto,whohopesthismighthelp A d with roughly the AdAM12—whichisexpressedphysiologi- designnoveltherapeuticapproachesto A ç AL lpha centauria mass of theearth, cally during embryogenesis—is often fibrosis. orbiting a star in the alphacentauri overexpressedinpathologieswithafi- 01. dulauroyetal.,“Lineagetracingandgenetic © 01.X.dumusqueetal.,“AnEarthmassplanetorbiting system—the closest broticcomponent,suchasmuscleand ablationofAdAM12+perivascularcellsidentifya 02.03.HighAccuracyRadialvelocityPlanetarySearch. theroleofAdAM12+cellswasnotknown,” 02.unitédedéveloppementdestissuslymphoïdesrendition).PMC).10.1038/nm.2848.doi:2012.,Nature Medicineinjury,”Howeverscleroderma.ordiseaseliverto ours (artist'stissueacuteduringcellsprofibroticofsourcemajoru/207-11.(CNRS491:Paris2012.,deNatureB,”d’astrophysiqueCentauriAlphaInstitut 04.EchelleSPectrographforRockyExoplanetand (CNRS/InstitutPasteur). StableSpectroscopicObservations. explainsLuciePeduto,2principalinvesti- 05.SpectromètreInfrarougepourleCanada-France- gatorofthestudy. Paris HawaiiTelescope(SPIRou/CFHT). Tofindoutmoreabouttheirfunction, theteamdevelopedtransgenicmicethat produced a fluorescent protein when contactInformatIon: contactInformatIon: IaP, Paris. AdAM12wasexpressed.uponinjuryin Institut Pasteur, Paris. François Bouchy themuscleandtheskin,theresearchers Luciepeduto > bouchy@iap.fr > lucie.peduto@pasteur.fr observed that expression of AdAM12
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