Offres d’accueil des labos - Post-docs - Doctorants
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01.02.10
Post-doctoral Scientist in Cystic Fibrosis and Calcium Signaling Research, Inserm U613, Brest
A 14-month post-doctoral position in the area of ion channel physiology and calcium signaling funded by the Region Bretagne is available immediately (February 2010) in the INSERM unit U613 located in the Medical Center of the University of Bretagne Occidentale in Brest (France).
This postdoctoral position is opened in the lab of Dr. Olivier Mignen to investigate the molecular and cellular mechanisms underlying calcium signaling in mammalian cells and its implication in Cystic fibrosis.
Contact : Olivier Mignen
27.01.10
Post doctoral position available in EUTrigTreat - Identification and therapeutic targeting of common arrhythmia trigger mechanisms - Institut du Thorax, Nantes
The project aims at elucidating the mechanisms by which a dysfunctional cardiac Na+ channel leads to aging-related structural changes in myocardial tissue and dilated cardiomyopathy by the use of knock(-in mouse models.
Contact : Flavien Charpentier
18.01.10
Offre de financement de thèse en métagénomique virale - Unité de recherche sur les maladies infectieuses et tropicales émergentes, Marseille
Projet de métagénomique virale dans le cadre de la création d'une nouvelle équipe (PathoVirome, Grant ERC)
Contact : Christelle Desnues
16.09.09
POST-DOCTORAL POSITION - Development and Immunogenetics team, JE 2537, Faculty of Medicine, Vandoeuvre-lès-Nancy, France
Deadline : 15th of December 2009
We are currently seeking a highly motivated post-doctoral scientist with a proven research track record to analyze the impact of chronic and acute stresses on the humoral immune response by studying 1) the effectors and the products of the V(D)J recombination process, 2) somatic hypermutations, 3) activation of B cells and 4) signal transduction in these cells. This post offers a unique opportunity to work within a healthy research team integrated in several European research networks focused on the study of the effects of stresses on human and animal physiology. The project is supported by grants from the Agence Nationale de la Recherche (ANR), a private company and the Centre National d’Etudes Spatiales.
More information
Contact : Dr Jean-Pol FRIPPIAT
02.11.09
2 years ANR-funded postdoctoral position in neuroscience ‘Metabolism, Imaging and Olfaction’ team - ‘Imaging and Modeling in Neurobiology and Cancerology’ lab - CNRS UMR8165
Deadline : 31/12/2009
Duration : 01/03/2010 - 28/02/2012
Location : Orsay (close suburb of Paris)
A postdoctoral research position funded by ‘Agence Nationale de la Recherche’ (ANR) for two years is available in our team for a highly motivated researcher with technical skills in electrophysiology. Our team and our lab run experiences at the neuroscience/physics interface. Our project is focused on the study of brain energy metabolism and plasticity in the olfactory bulb and the hippocampus in rodents. The focus of this postdoctoral work will be the neuroenergetic coupling during hippocampal LTP with the use of electrophysiology, biosensors for lactate and laser Doppler flowmetry for complementary data acquisitions in vivo.
Application should include a CV, a description of previous research work, a list of publications and at least one letter of reference. Please, send your application electronically in a single file to Dr. Hirac GURDEN
Techniques:
Combined electrophysiological, electrochemical and optical recordings
Profile: PhD in neuroscience with a previous experience in in vivo electrophysiology.
29.10.09
Post-doctoral position for large scale genetics, Institut Pasteur, Paris
An ANR funded post-doctoral position in systems biology of eukaryotic cells is available starting March 2010 at the Institut Pasteur, in the "Génétique des Interactions Macromoléculaires" laboratory (CNRS-URA 2171). Systems biology is a set of tools that should allow the integration and interpretation of large amounts of experimental data. We are using a novel method for quantitative estimation of binary genetic interactions to currently obtain a new set of such large scale data. This method (Genetic Interactions Mapping, GIM) scores the growth phenotype of yeast (S. cerevisiae) cells that contain two mutations as compared to the corresponding single mutant cells (Decourty et al., PNAS, 2008). Such genetic interactions are at the heart of understanding the complex relationships between cellular pathways because they are a direct readout of how an eucaryotic cell adapts to perturbations (in this case gene deletions or gene alleles with modified function). The post-doctoral fellow should be qualified in data analysis, programming and statistics. His or her main project will be the analysis and interpretation of about 2 million genetic interaction measurements by integrating the results with large-scale data sets on systematic localization of proteins, analysis of transcripts, protein interactions or chemogenomics. We hope such an analysis will lead to the discovery of novel links between cellular pathways and to novel concepts about the relationship between genetic background and phenotype. Predictions of function or functional interactions will be next verified by focused in vivo experiments using the yeast S. cerevisiae as a model organism.
Contact : Cosmin Saveanu
26.10.09
Postdoctoral position available in CNRS - UMR 8160 "Neural correlates of emotion, empathy and social interactions"
More information
Contact : Harold Mouras
22.10.09
Post-doctoral position at the Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC) in Strasbourg
Retinoic Acid signalling Pathways in Stem Spermatogonia Ontogenesis and Differentiation
The funding is available for duration of up to 36 months.
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Contacts : Dr Norbert B. GHYSELINCK, Pr Manuel MARK
24.09.09
POST-DOCTORAL POSITION AVAILABLE IN CELLULAR AND MOLECULAR BIOLOGY
LABORATOIRE DE BIOLOGIE DU DEVELOPPEMENT - UMR 7622
The candidate will be involved in isolation, culture and immortalisation experiments on the three species. He will also be in charge of the functional tests on the cell lines.
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Contact : Dr. Thierry Jaffredo
24.09.09
POST-DOCTORAL POSITION (CGM – CNRS Gif-sur-Yvette, France)
Mechanisms involved in programmed genome rearrangements
Deadline for application: 01 January 2010
A two-year postdoctoral position is available at the Centre de Génétique Moléculaire, to study the molecular mechanisms responsible for programmed DNA elimination during genome assembly in the ciliate /Paramecium tetraurelia/. The project will be focused on the role of a domesticated transposase that we recently identified as a key player in this process. The candidate will be invited to use a combination of reverse genetics, cellular, molecular and biochemical approaches. A good expertise in the biochemistry of protein-nucleic acids interactions would be appreciated.
The position is available immediately, although a starting 2010 date is also possible.
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Contact: Mireille Bétermier
11.09.09
POSTDOCTORAL RESEARCH POSITIONS (CNIC / UMR5228 CNRS-Université de Bordeaux)
Regulation of Ca2+ signalling in cerebral artery by gravity changes - CEREBROARTERIAL PHYSIOLOGY
The position is available for two years (full time) and salaries (based on the national scale) will depend on qualifications. Experience with either image analysis, confocal microscopy, Ca2+ signaling, telemetric measurement or cell physiology is desirable. Candidates will have a PhD, good organizational and analytical skills, a good practice of English and should have a keen interest in integrating and understanding of the vascular physiology.
More information
Contact : Jean-Luc MOREL
08.09.09
ANR funded post-doc position at Institut Pasteur, Molecular Biology
One postdoctoral position is available immediately to investigate chromosome organization in yeast. The postdoc will be a member of an interdisciplinary team, whose goals are to analyze and model chromosomes organization/dynamics using an integrated approach that combine multiple experimental techniques and computational tools (Berger et al., Nat. Methods, 2009; Koszul et al., Cell, 2008). Experience in molecular techniques (such as 3C derivatives) and/or yeast genetics is desirable. Knowledge in statistical analysis of complex matrix interactions would useful. Competitive salary is provided by the French National Research Agency, and the position would be for two years, starting asap or January 2010.
Please contact us for more information about the project.
Contact : Romain Koszul
22.07.09
A 3 years post-doctoral position is available to start within the next 4 months in the team Cell Biology of Synapse (Antoine Triller) at the Institut de Biologie de l’Ecole Normale Supérieure (IBEns)
Novel mechanisms for the deleterious effect of misfolded proteins in neurodegenerative diseases
The project is aimed to document the binding, lateral diffusion and internalization of structurally characterized pathological protein aggregates to the plasma membrane in a dynamic manner using single-molecule imaging, calcium imaging and electron microscopy. We intend to dissect the binding process of Huntingtin (Htt), alpha-synuclein and A-beta protein aggregates to the membrane, measure the affinity of the polypeptide aggregates for membrane components and relate binding to the structure of the aggregates. We also aim to document the consequences of polypeptide aggregates binding to the membranes, in particular determine whether the aggregates breach plasma membranes and to what extent. To better understand the deleterious physiological consequences of aggregates binding to neuronal membranes we plan to determine whether pathologic protein aggregates have the ability to build up larger structures on plasma membranes that might possess intrinsic signaling properties or whether they recruit membrane components involved in signaling pathways by accessing the diffusion parameters of the different Htt, alpha-syn and A-beta protein aggregates and determining with what structures they co-localize.
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Contact : Antoine Triller
15.07.09
ANR funded research scientist in cellular and molecular biology
We are recruiting an ANR funded research scientist (maximum of 5 years postdoctoral experience) to work on cell and molecular biology of Trypanosoma brucei. The specific aims of the project are to characterise the biogenesis of the flagellar pocket of T. brucei and to assess what aspects of the pocket can be utilised to define how the pocket is made and maintained. This will be done by microscope based analysis of the pocket and the identification and characterisation of partner proteins of BILBO11. The approaches will include light and laser microscopy, cross-linking biochemistry and yeast two-hybrid screening. He/she must have excellent molecular and cell biology skills and good knowledge of the molecular biology unique to trypanosomes. Also he/she must have knowledge in the making, testing and screening of modern yeast two-hybrid libraries. The first stages of the work will involve the construction and screening of a two-hybrid library and the production of samples for mass spectrometry and antibody generation.
He/she must be meticulous, enthusiastic and able to communicate in English and French. This job therefore requires skills of an experienced worker who is capable of working independently and with a team and is able to push the project forward. He/she will work for two years with a starting date of Spring/Summer 2010 or exceptionally autumn/winter 2009.
Contacts :
Mélanie Bonhivers or Derrick R. Robinson
24.06.09
Offre d’accueil d’un chercheur statutaire, UMR8621, Orsay
L'équipe de « Métabolisme Energétique des Streptomyces » (UMR 8621 CNRS/université Paris XI) de l’Institut de Génétique et Microbiologie de l’Université Paris XI à Orsay, souhaite accueillir un chercheur statutaire CR2 ou CR1, un microbiologiste, ayant un intérêt intellectuel pour la régulation du métabolisme central ainsi que des compétences en biologie moléculaire, afin de renforcer une équipe de recherche étudiant la régulation de la biosynthèse d’antibiotiques chez la bactérie d’intérêt industriel, Streptomyces, et plus précisément les liens existant entre le métabolisme primaire, qui fournit les précurseurs entrant dans la biosynthèse d’antibiotiques, et le métabolisme secondaire caractérisé par l’assemblage de ces précurseurs pour la biosynthèse d’antibiotiques. Le chercheur aura un rôle central au laboratoire, en participant au travail expérimental, à la formation d'étudiants, à l’organisation du laboratoire ainsi qu’à la réflexion scientifique et à l'élaboration des projets de recherche de l'équipe.
En savoir plus
Contact : Dr Marie-Joelle VIROLLE
08.06.09
Postdoctoral Position in Lyon, France "Metabolomics of C. elegans"
A postdoctoral position is open at the Center for Molecular and Cellular Genetics, Lyon, France (Segalat lab), to pursue our work in C. elegans NMR metabolomics. This is a joint project with the Lyon Center for High Field NMR
More information
13.05.09
Multimodal MRI of the spinal cord - Postdoctoral position at CRMBM (UMR CNRS 6612, Marseille, France)
A 2-year postdoctoral position is available in the Centre de Résonance Magnétique Biologique et Médicale (CRMBM, dir. Pr PJ. Cozzone) in Marseille, France.
The main goal of the project is to improve the non invasive characterization of the spinal cord (SC) traumatic pathologies through the assessment of structural, vascular and metabolic MR informations.
The candidate will develop and/or validate MR techniques for mouse SC investigations at very high field (11.75T) and participate to the transfer to human SC study (1.5T and 3T). He/she will be integrated in a multidisciplinary experienced team of MRI method scientists, engineers and biologists.
The candidate should possess a Ph.D. in an appropriate discipline, such as physics, biomedical engineering, or biology. Competence in MR physics, MR engineering, physiology or biology is advantageous. Experience with post-processing environments like IDL or Matlab will be necessary. Skills in pulse sequence programming would be greatly appreciated.
The position is supported by a grant from the ANR (Agence Nationale de la Recherche) and is funded from July 1st 2009 for a period of two years.
A full description of the job
03.04.09
Post-doctorats à pourvoir au laboratoire de Microbiologie et Génétique Moléculaire, CNRS UMR 2585, Campus AgroParis Tech, Grignon
Profil recherché : biologie moléculaire, biochimie des lipides, ingénierie métabolique
Sujet de recherche : biologie systémique des lipides chez les levures
09.02.09
Offre d'accueil pour un doctorant à l'URA 2096, iBiTec-S/SB²SM/LSOD, CEA Saclay
"Le paradoxe NO-Synthase : de la Signalisation Cellulaire au Stress Oxydant"
Le monoxyde d'azote (NO) est un médiateur impliqué dans de nombreux processus physiologiques chez les mammifères (pression artérielle, communication neuronale?). NO est également associé au développement de nombreuses pathologies (maladies cardiovasculaires, neurodégénératives, cancers?). Cette double activité représente un paradoxe encore inexpliqué qui est au c?ur de nombreux projets de recherche biomédicale et pharmaceutique. NO est exclusivement synthétisé par une famille d'enzyme, les NO-Synthases (NOS), associées à chaque activité biologique. Toutes les études fonctionnelles et structurales des NOSs menées à ce jour se sont révélées incapables d'élucider les raisons de ce paradoxe. Dans ce contexte, notre laboratoire développe un projet de recherche dont le but est de déchiffrer le mécanisme moléculaire de différentes NO-Synthases et d'identifier les facteurs qui contrôlent leur activité biologique. Nos projets s'appuient sur la combinaison de plusieurs méthodologies allant de la Biologie Moléculaire à la Biophysique Structurale. Nous développerons également des approches innovantes de cinétiques ultra-rapides.
Contacts:
Jérôme Santolini ou
Pierre Dorlet
actualisée le 04.02.09
Post-doc position : Gene-environment interactions in development and evolution, Institute of Developmental Biology and Cancer - Nice
Contact : Christian Braendle
