Offres d’accueil des labos - Post-docs - Doctorants
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04.09.12
Two post-doctoral positions are available in the team of Jean-Philippe GIRARD at IPBS (Team “Vascular Biology: Endothelial Cells, Inflammation and Cancer”).
Topic 1 : “Characterization of high endothelial venules (HEVs) : specialized blood vessels for lymphocyte extravasation in immunity and inflammation”. HEV blood vessels support high levels of lymphocyte recruitment in lymphoid organs and chronically inflamed tissues. Interfering with the development and/or maintenance of HEVs in chronically inflamed tissues is therefore likely to provide therapeutic benefits in many distinct human chronic inflammatory diseases (rheumatoid arthritis, inflammatory bowel diseases, atherosclerosis, bronchial asthma, chronic vascular rejection of kidney and heart grafts,...). However, very little is known yet about the molecular mechanisms regulating formation of HEV blood vessels. We recently discovered that CD11c+ dendritic cells play a critical role in the maintenance of HEV characteristics in adult mouse lymph nodes (Moussion and Girard, Nature 2011). The major objective of the current project is to further define the molecular mechanisms involved in the induction and maintenance of HEVs, through the use of innovative approaches (in vivo cell depletion using transgenic mouse lines, generation of mixed bone marrow chimeras, immunohistology and intravital microscopy).
Topic 2: “Regulation and function of IL-33, an IL-1 family cytokine with critical roles in type-2 innate immunity and allergic inflammation”. IL-33 is a novel member of the IL-1 family, that appears to play important roles in the activation of type-2 innate lymphoid cells (ILC2, nuocytes) and in the initiation of allergic diseases such as asthma. Our team discovered IL-33 in 2003 as a nuclear factor from HEVs and has made major contributions in the field. We were the first to describe IL-33 as an atypical chromatin-associated nuclear cytokine (Carriere et al., PNAS 2007, 214 citations, Top 1% Immunology). In addition, we went against the dogma in the field, to demonstrate that IL-33 is not activated by caspase-1/inflammasome like other IL-1 family members and that it may rather function as an alarm signal (alarmin) released upon cellular damage, to alert cells of the innate immune system of tissue damage during trauma or infection (Cayrol and Girard, PNAS 2009, 110 citations, Top 1% Immunology). Finally, we recently demonstrated the role of inflammatory proteases in the generation of mature bioactive forms of IL-33 (Lefrançais et al., PNAS 2012). The major objective of the current project will be to further characterize IL-33 regulation and mechanisms of action in vivo, through the use of multidisciplinary approaches (molecular and cellular biology, flow cytometry, cell sorting, high-throughput proteomics, models of allergic inflammation in IL-33-deficient mice recently generated by the team, ….).
Requirements: PhD in Immunology/Immunopathology (or equivalent) with strong background in animal experimentation (in vivo analysis of mouse models). Previous experience in flow cytometry (topics 1 and 2) and generation of bone marrow chimeras or intravital microscopy (topic 1) will be appreciated.
Contracts: 2 to 3 years full time post-doctoral positions funded by ANR (starting date: between 01/10/12 and 01/01/13)
How to apply: Please, send your curriculum vitae, technical expertise and list of publications to
Contact : Jean-Philippe Girard
12.06.12
Two available postdoc positions in the Institute of Plant Integrative Biology (IBIP) of Montpellier, starting late Fall 2012
The candidates should be highly motivated and have a strong background in plant molecular biology. Expertise in transcriptomics, proteomics and genetics would be appreciated.
Both projects will be held in the group of Catherine Curie, in the SupAgro/INRA campus, place Viala, in Montpellier, France (http://www1.montpellier.inra.fr/ibip/bpmp/equipes/tsf.htm)
The first postdoc will study the regulatory processes controlling manganese and iron uptake by key transporters of the NRAMP and ZIP families in Arabidopsis. The complex interplay of Fe and Mn will be assessed through transcriptomics and proteomics analyses in collaboration with the lab of Wolfgang Schmidt in Taipei. This postdoc position is funded for 3 years by an International French-Taiwanese grant from the Agence Nationale pour la Recherche (ANR).
The second postdoc will focus on the cellular mechanism driving manganese trafick to the chloroplast as it is a crucial cofactor to the oxygen evolving complex of Photosystem II. The role of candidate proteins such as the Arabidopsis NRAMP manganese transporters will be investigated by a combination of reverse genetics, cell biology and molecular physiology; genetic screens will also be designed to identify new players. This postdoc position is funded for 2 years by an International French-Taiwanese grant from the Agence Nationale pour la Recherche (ANR).
Please send a curriculum vitae including a list of publications and research interest, and the names and e-mail addresses of two referees to :
Catherine Curie
Contact : Catherine Curie
01.06.12
The Group “Microbial Systems Ecology” in the Department of Environmental Microbiology is seeking a highly motivated Postdoc with expertise in phage (virus) biology and ecology as well as in the corresponding molecular techniques.
The Helmholtz Centre for Environmental Research - UFZ is a research institution within the Helmholtz Association. It provides scientific contributions to the safeguarding of the natural basis of life and of human development potentialities for current and future generations under the challenges of global and climate change. In this way the UFZ contributes towards a sustainable development.
The anticipated starting date is summer 2012, funding is available for 3 years. Our group performs research into various aspects of microbial ecology such as plant-microbe interactions, protistan ecology, biodegradation, HGT, bacteriophage ecology and theoretical microbial ecology.
The campus of the University of Bordeaux is a leading neuroscience research center with excellent infrastructural support and interaction partners, in particular in the field of cellular neuroscience and high-resolution microscopy.
The place of work is Leipzig, Germany
Please send your complete application documents (curriculum vitae, list of publications, statement of research interests and the names and e-mail addresses of two referees (one of which should be your PhD supervisor)under the code digit 39/2012 to :
the personnel department,
P.O. Box 500136,
D-04301 Leipzig, Germany
Deadline : 29.06.12
Contact : Antonis Chatzinotas
15.05.12
postdoc/engineer position in super-resolution microscopy at the Interdisciplinary Institute for Neuroscience in Bordeaux, for an initial period of 2 years.
We seek a highly motivated postdoctoral scientist/engineer to reinforce our research efforts in super-resolution microscopy for neuroscience. The focus of the project is to develop super-resolution live-cell imaging modalities such as STED and PALM for advanced applications in synapse biology.
The candidate should have a strong background in optics and interest in neuroscience. He or she will work in a highly interdisciplinary research environment, including optical engineers, computer scientists and neurobiologists.
The project is headed by the teams of Jean-Baptiste Sibarita and Valentin Nägerl at the Interdisciplinary Institute for Neuroscience t the University of Bordeaux. The position is initially funded for two years through the France Bioimaging Initiative and hosted by the Bordeaux Imaging Center headed by Daniel Choquet
The campus of the University of Bordeaux is a leading neuroscience research center with excellent infrastructural support and interaction partners, in particular in the field of cellular neuroscience and high-resolution microscopy.
Please send a CV and a brief statement of research experience & interest to:
Contact : Valentin Nägerl
Contact : Jean-Baptiste Sibarita
15.05.12
postdoc/engineer position in super-resolution microscopy at the Interdisciplinary Institute for NeuroScience in Bordeaux, for an initial period of 18 months.
We seek a highly motivated postdoctoral scientist/engineer to reinforce our research efforts in super-resolution microscopy for neuroscience. The focus of the project is to develop 3D multi-color single molecule-based super-resolution live-cell microscopy for advanced applications in synapse biology.
The candidate should have an experience in single molecule microscopy and interest in neuroscience. He or she will work in a highly interdisciplinary research environment, including optical engineers, computer scientists and neurobiologists.
The project is headed by the teams of Jean-Baptiste Sibarita and Daniel Choquet at the Interdisciplinary Institute for Neuroscience at the University of Bordeaux. The position is initially funded for 18 months by the Regional Council of Aquitaine.
The campus of the University of Bordeaux is a leading neuroscience research center with excellent infrastructural support and interaction partners, in particular in the field of cellular neuroscience and high-resolution microscopy.
Please send a CV and a brief statement of research experience & interest to:
Contact : Jean-Baptiste Sibarita
