Keywords

• Structure of macromolecules, sequence/structure/function/evolution relationships
• Integrative structural biology: high-resolution structural characterization (cryo-electron tomography, crystallography, NMR), AFM, imaging and spectroscopy in relation to the functional properties of biological macromolecules; correlative approaches.
• Cellular structural biology, cryo-electron tomography, Electron Paramagnetic Resonance in cellulo, NMR in cellulo
• Structural and functional analysis of single molecules or molecular assemblies
• Dynamics of macromolecules and their complexes, non-equilibrium processes
• Molecular and structural basis of nucleic acid functions
• Structural bioinformatics, dynamics, modeling and molecular evolution
• Protein engineering and macromolecule function engineering
• Enzyme mechanisms, enzymology
• Ligand-protein interaction, allosteric mechanisms, molecular effector/drug design
• Membranes and membrane proteins, structures, molecular mechanism of transport across biological membranes, bioenergetics
• Proteomics and systematic approaches to supramolecular assemblies and post-translational modifications
• Biophysical and biochemical approaches to describe the functions and dynamics of molecules or biological assemblies in their natural or reconstituted environments
• Structures, assemblies and mechanisms in signal transduction, gene expression, regulation and repair
• Molecular and structural microbiology and virology
• Intra- and inter-species bacterial metabolism
• Metabolic pathways and biosynthetic processes, metabolic networks, systemic approaches to cellular metabolism, including pathological processes
• Structures and functions of glycans and enzymes associated to their biosynthesis and modification
• Synthetic biology, design of new biological systems, controlled alteration of metabolic pathways and macromolecule production routes, biosensors