Cette conférence se déroulera le 24
novembre 2010 à Rennes. Elle sera
animée par Aubin Penna du laboratoire de Michael
Cahalan - department of Physiology and biophysics, university of
California, Irvine, Ca. Il travaille désormais dans l'IFR
à IRSET, EA-4427 SERAIC, université de Rennes 1.
Ca2 -release-activated Ca2 (CRAC) channels underlie sustained
Ca2 signaling in lymphocytes and numerous other cells after Ca2
liberation from the endoplasmic reticulum (ER). RNA interference
screening approaches identified two proteins, Stim and Orai, that
together form the molecular basis for CRAC channel activity. Stim
senses depletion of the ER Ca2 store, aggregates and physically
relays this information by translocating from the bulk ER to
junctions adjacent to the plasma membrane (PM), and Orai embodies
the pore of the PM calcium channel.