Organs and organoids chips (MED-OOC) PEPR
Revolutionising medicine with organs- and organoids-on-chips
Faced with the limitations of the models currently used for clinical trials, the MED-OOC research programme aims to develop a new generation of miniaturized biological models based on human cells. These devices, which combine cell engineering, microfluidics and cutting-edge technologies, promise to faithfully reproduce the functions of human organs and finely model human pathologies, paving the way for more personalized, effective and ethical medicine.
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The development of organs- and organoids-on-chip is based on advances in cell biology, microtechnology and imaging. Their aim is to recreate a controlled microenvironment capable of simulating the real physiological dynamics of an organ, or even several interconnected organs. Three major scientific challenges are addressed: integrating sensors for real-time monitoring, customizing chips using patients’ cells, and developing multi-organ, multi-function approaches.
The applications cover a wide spectrum: therapeutic decision support for cancers, monitoring of pancreatic transplants in type 1 diabetes, and the study of metabolic imbalances linked to chronic diseases. The organ-on-chip technology is also a powerful tool for developing and testing new therapies.
By helping to reduce animal testing, personalize care and strengthen the competitiveness of the biomedical field, MED-OOC is fully in line with the challenges of public health, therapeutic innovation and scientific sovereignty.
