Covid-19: Who Should we Vaccinate First to Slow the Spread of New Variants?


During a pandemic like the one caused by SARS-CoV-2, it is impossible to quickly vaccinate the entire population. Which individuals should be vaccinated first? The most fragile in order to reduce their risk of becoming ill? The youngest and most active individuals in order to limit epidemic progression? The decision is further complicated if we adopt an evolutionary standpoint: vaccination induces a selection pressure that can favour certain strains of the virus, or variants, that are resistant to vaccines.1 Is it possible to choose vaccine strategies that can slow down this evolution? This question is all the more crucial given that vaccine coverage against Covid-19 remains low in certain countries. On 18 January 2022, scientists from the Centre d’Ecologie Fonctionnelle et Evolutive (CNRS/Université de Montpellier/EPHE-PSL/IRD) published a theoretical framework in PNAS that assesses the impact of various vaccination strategies on the rate of emergence for new variants. For instance, in the case of SARS-CoV-2, the strategy of vaccinating older individuals as a priority appears highly effective, as it minimizes both selection for a resistant variant and overall mortality. This study underscores the importance of taking the evolutionary dynamics of the virus into consideration as a complement to an exclusive focus on the dynamics of the epidemic.2

  • 1Similar to how the unreasonable use of antibiotics can foster antibiotic resistance among bacteria.
  • 2For instance, solely monitoring figures relating to the number of cases, hospitalized patients, and deaths, in addition to positive rates, R0, etc.

Targeted vaccination and the speed of SARS-CoV-2 adaptation. Sylvain Gandon and Sébastien Lion. PNAS, 18 january 2022. DOI : 10.1073/pnas.2110666119


Sylvain Gandon
CNRS researcher
Sébastien Lion
CNRS researcher
CNRS Press Office