National research programme Cell identities and destinies (PEPR Cell-ID)
Analysing the fate and identity of cells to intercept diseases
Understanding how a cell acquires, maintains or loses its identity during development is at the heart of the Cell-ID research programme. By studying the early deviations that lead to pathologies, it paves the way for interceptive cellular medicine. The goal is to identify the warning signs of a disease before it manifests itself, in order to intervene earlier and more effectivelyfor the patient.
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Exploring cellular identities and destinies means delving into the heart of life itself: understanding how a cell specialises, interacts with its environment and contributes to the formation of healthy tissue. Scientists are drawing on a range of disciplines – biology, physics, chemistry, mathematics, computer science and medicine – to decipher the molecular and epigenetic mechanisms that govern cellular trajectories. The challenge is immense: to observe and model,
in time and space, at the single-cell level, how a cell follows or deviates from its physiological destiny.
The potential applications are numerous and promising. By initially targeting paediatric brain cancers, Cell-ID aims to improve early diagnosis, reduce the side effects of current treatments and offer more appropriate care. The expected benefits are significant: earlier detection of the disease, anticipation of relapses, personalised treatment and the development of predictive tools. Cell-ID’s advances could also benefit other diseases, such as neurodegenerative or inflammatory conditions.
PEPR Cell-ID : explorer les identités et destins cellulaires
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For more information
- Quand les cellules déraillent : comprendre comment les destins cellulaires se construisent ou se déconstruisent, interview with Geneviève Almouzni in CNRS Info (26/01/24)