Triglycerides control neurons in the reward circuit


Energy-dense food, obesity and compulsive food intake bordering addiction: the scientific literature has been pointing to connections between these for years. Scientists at the CNRS and Université de Paris have just shown for the first time how fatty nutrients act on the brain in the reward circuit. Published in Cell Metabolism on 5 March 2020, these results shed new light on the connection between food and eating disorders.

This recent work, directed by scientists at the Unité de biologie fonctionnelle et adaptative (CNRS/Université de Paris)1 2 , show that triglycerides, the nutrients that constitute animal fats, vegetable oils and dairy products, interact with certain neurons in the reward circuit and reduce their excitability in mice, both in vitro and in vivo. These neurons carry a specific type of dopamine-receptor, and their activity strengthens reward-seeking behaviour. The scientists also observed that the manipulation of triglyceride levels in the brain of mice changes many behaviours associated with dopamine, like pleasure and motivation to collect food.

The study is completed by observations of brain activity in humans in response to a food odour compared with their blood triglyceride level after a meal. The research team has shown that activity in the prefrontal cortex, one of the regions of the reward circuit that makes connections between a food’s odour, its taste and the pleasure that it causes, is directly correlated with the quantity of triglycerides circulating in the blood. The higher it is, the lower the prefrontal cortex’s response to a food odour. This suggests that the activity of important brain structures in the reward system can be directly modified by a lipid nutrient.

Usually, triglycerides only circulate in the blood after a meal. The exception is obese patients, for whom doctors often observe abnormally high triglyceride levels all day long. In this context, this study offers a new framework for potentially explaining why ever-wider access to rich foods may contribute to the establishment of compulsive dietary problems and increase obesity rates.

Food is a source of various circulating nutrients, including triglycerides (TG), which are the postprandial (ie after a meal) lipid source. TG can enter the brain, where they act directly on the neurons that release or respond to dopamine (DA). This mechanism is lipoprotein lipase-mediated (LPL) TG hydrolysis and is translated by inhibition of these neurons in the reward system.
In rodents when TG act on neurons in the reward system that exerts control over dopamine-dependant behaviours (pleasure from eating, response to psychostimulants, etc.). In humans, postprandial TG variations are narrowly correlated with the way the brain perceived and responds to a dietary stimulus.

© Chloé Berland et al.


  • 1
  • 2Researchers at the Centre interdisciplinaire de recherche en biologie (CNRS/INSERM/Collège de France), of the Institut de neurosciences cognitives et intégratives d’Aquitaine (CNRS/Université de Bordeaux) and Laboratoire neurosciences Paris-Seine (CNRS/INSERM/Sorbonne Université) participated in this work, and outside France, from the Helmholtz Diabetes Center in Munich, Yale University, the University of California San Diego and Novo Nordisk.

Circulating triglycerides gate dopamine-associated behaviours through dopamine receptor type 2 (DRD2)-expressing neurons. Chloé Berland, Enrica Montalban, Elodie Perrin, Mathieu Di Miceli, Yuko Nakamura, Maud Martinat, Mary Sullivan, Xue S. Davis, Mohammad Ali Shenasa, Claire Martin, Stefania Tolu, Fabio Marti, Stephanie Caille, Julien Castel, Sylvie Perez, Casper Gravesen Salinas, Chloé Morel, Jacob Hecksher-Sørensen, Martine Cador, Xavier Fioramonti, Matthias H. Tschöp, Sophie Layé, Laurent Venance, Philippe Faure, Thomas S. Hnasko, Dana M. Small, Giuseppe Gangarossa et Serge Luquet. Cell Metabolism, 5 March 2020.


Serge Luquet
CNRS Researcher
Giuseppe Gangarossa
Université de Paris researcher
François Maginiot
CNRS Press Officer